Pharmacological treatment options for mast cell activation

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Zabetian and N. Kalani and A. Khalili and R anaesthesia with propofol is associated with a lower incidence of PONV when compared with inhalational anaesthetic. However, it is unclear regarding the dose response of propofol when used as an antiemetic, and how propofol should be administered in the perioperative period for its antiemetic effects. Propofol is known to exert an antiemetic effect even though the exact mechanism is still unclear. One study reported that propofol reduces PONV by blocking the 5-hydroxy-tryptamin-3 receptor of the serotonergic system, 20 , 21 while others reported that inhibition of the chemoreceptor trigger zone and vagal nuclei, which are directly related to nausea and vomiting, is associated with the 2019-10-15 · Cite this: Sub-hypnotic Dose of Propofol as Antiemetic Prophylaxis Attenuates Intrathecal Morphine-induced Postoperative Nausea and Vomiting, and Pruritus in Parturient Undergoing Cesarean Section Antiemetic Effects of Midazolam and Propofol during Spinal Anesthesia on Women Undergoing Elective Cesarean Sections.

Antiemetic effect of propofol

Rescue medication: • Propofol bolus (short-acting). • Haloperidol. • Ondansetron. Overview of antiemetic medications. • Aprepitant – NK-1 receptor antagonist.

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The antiemetic effect of propofol is attributed to modulation of subcortical pathways to inhibit nausea or its direct depressant action on the vomiting center . The results of our study are consistent with other studies, conducted in different settings, in terms of antiemetic rescue therapy requirements and trends of dexamethasone preventive effect [ 22 , 23 , 25 , 30 , 31 ].

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Helmers H. et al Superior prolonged antiemetic prophylaxis with a four-drug propofol, which had a short lasting effect. …alla 4 Hammas, Bengt: Experimental and clinical studies on the antiemetic effects of propofol. 2001.

However, low dose propofol (10 mcg/kg/min) by continuous infusion has shown inconsistent results as an antiemetic (2,3). There is no published data on low dose propofol in combination with other antiemetics. The antiemetic effect of propofol is attributed to modulation of subcortical pathways to inhibit nausea or its direct depressant action on the vomiting center .
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However, its mechanism of action in this context is still not well understood. Antiemetic effect of propofol. Borgeat A. Comment on Anaesthesia. 1996 Jun;51(6):554-7.

regarding analgesic and antiemetic requirements. Later Comparative Study of Antiemetic Effect of Ramosetron With Combination of Patients will be induced with injection propofol 2 mg/ kg mixed with xylocard The Effect of Multimodal Anti-emetic Protocol on Postoperative Nausea and regional anesthesia, midazolam & propofol, hydration & oxygen supplement, Swedish University dissertations (essays) about THESIS ON PROPOFOL. Search and Experimental and clinical studies on the antiemetic effects of propofol.
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THESIS ON PROPOFOL - Dissertations.se

Postoperative nausea and vomiting (PONV) are unpleasant, often underestimated side effects of anaesthesia and surgery, not devoid of medical complications. Prevention with antiemetics is only partially effective. Propofol has been shown recently to possess antiemetic properties in several situations. In this prospective, randomized, controlled trial, we have compared the antiemetic efficacy of We report on the use of propofol in 35 patients. In 22 patients, propofol was used for palliative sedation when treatment with benzodiazepines had failed. The mean dose range during treatment was between 0.90 and 2.13mg/kg/h.

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Propofol antiemetic use for induction and maintenance of anesthesia has been shown to be associated with a lower incidence of postoperative nausea and vomiting (PONV) when compared to any other anesthetic drug or technique.

Propofol has been shown recen 2020-08-24 Propofol Antiemetic effects The incidence of postoperative nausea and vomiting (PONV) is decreased with propofol administration regardless of the type of anesthetic. Nausea and vomiting in the PACU can be successfully treated with 10-20 mg of propofol IV. Propofol is known to possess direct antiemetic effects.